منابع مشابه
Harvey Cushing Treated the First Known Patient With Carney Complex
Context Carney complex (CNC) is a syndrome characterized by hyperplasia of endocrine organs and may present with clinical features of Cushing syndrome and acromegaly due to functional adrenal and pituitary gland tumors. CNC has been linked to mutations in the regulatory subunit of protein kinase A type I-alpha (PRKAR1A) gene. Design Tissue samples were taken from the hypothalamus or thalamus ...
متن کامل[Carney complex].
Carney complex (CNC) is an autosomal dominantly inherited syndrome characterized by spotty skin pigmentation, cardiac and cutaneous myxoma, and endocrine overactivity. Skin pigmentation includes lentigines and blue nevi. Myxomas may occur in breast, skin and heart. Cardiac myxomas may be multiple and occur in any cardiac chamber, and are more prone to recurrence. The most common endocrine gland...
متن کاملPITUITARY DEPENDENT CUSHING\'S SYNDROME IN IRAN
During a 5-year experience with 32 adrenal tumors with different basic problems in the Department of Endocrinology , Taleghani Hospital, 25 were found pituitary dependent Cushing's syndrome, "Cushing's disease." The treatment of patients with Cushing's disease depends on the presence or absence of pituitary tumor. Ifno pituitary tumor is demonstrated, irradiation can be given to the pituit...
متن کاملA Mouse Model for the Carney Complex Tumor Syndrome
Carney complex is an autosomal dominant neoplasia syndrome characterized by spotty skin pigmentation, myxomatosis, endocrine tumors, and schwannomas. This condition may be caused by inactivating mutations in PRKAR1A , the gene encoding the type 1A regulatory subunit of protein kinase A. To better understand the mechanism by which PRKAR1A mutations cause disease, we have developed conventional a...
متن کاملCushing’s Syndrome Revealing Carney Complex: A Case Report
A 35-year-old female was referred in Mai 1999 to our department for oligomenorrhea, baldness and weight gain evolving over 2 years. She doesn’t have any medical record and she is not taking any specific treatment especially corticosteroids. In her familial history, we found a sister and a niece with breast cancer and a brother died of colon cancer. The physical exam revealed a moon face, a mode...
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ژورنال
عنوان ژورنال: American Journal of Surgical Pathology
سال: 2017
ISSN: 0147-5185
DOI: 10.1097/pas.0000000000000748